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lumbar stenosis, inflammatory biomarker, clinical outcome, MFRS and LF.
Objective: Modified Fenestration-Restorative Spinoplasty (MFRS) technique is an alternative to
lumbar stenosis treatment, providing the equal decompression comparing with laminectomy
techniques, without the implant, less expensive and complication rates. The purpose of this study was
to determine which technique gives better inflammation and clinical outcome based on high sensitive
C-Reactive Protein biomarker (hsCRP) and Prostaglandin E2 (PGE2), Visual Analog Scale (VAS) of
the day 7th postsurgery and ODI scores 3rd month post surgery.
Methods: This study design is an experimental pretest-posttest randomized control group design.
Results: This study results showed that the mean levels of hsCRP day 7th postsurgery were differ
significantly between MFRS (23,09 ± 15,3 mg/L) compared to LF (39,53 ± 24,4 mg/L). Likewise for
the mean levels of PGE2 day 7th postsurgery were differ significantly between MFRS (491,39 ± 528,5
pg/ml) compared to LF (1103,7 ± 1033,6 pg/ml) at the significance level of p <0.05). MFRS clinical
outcomes better than LF (p <0.05), for means of VAS value day 7th postsurgery and ODI score 3rd
month postsurgery. Perioperative variable analysis shows that MFRS was better than LF in: length of
surgery, blood loss, postsurgery Hb and patient length of stay (p<0,05).
Conclusions: MFRS technique is an alternative technique of lumbar stenosis treatment better than the
LF, in terms of improved levels of hsCRP and PGE2, leading to faster clinical outcomes
improvement, less complications and lower costs. MFRS technique should be used as a treatment of