Epilepsy Surgery in Indonesia: Achieving a Better Result with Limited Resources

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Zainal Muttaqin

Keywords

epilepsy. Interictal, subdural grid, implanted, seizure

Abstract

Objective: There is around 1.5 million of epileptic in Indonesia within prevalence of 0.5-0.6%. Of
these 440,000 will be intractable, and 220,000 of them are potential candidates for epilepsy surgery
(ES). A decade has passed since the first ES performed on July 1999 and the number increases every
year reaching of 35-47 ES per year in 2007-2009. Despite the excellent results, all of these ES were
still performed in Semarang (Diponegoro University) while the patients were from all part of
Indonesia. The major reason behind the unavailability of ES in most part of the country should be
discussed for the sake of future development of ES in Indonesia.
Methods: Epilepsy surgery was started in July 1999 with anterior temporal lobectomy for a 34 Y-old
female with left mesial temporal sclerosis (MTS) causing a long standing intractable seizures. The
number of cases increases every year. Until the end of 2009, there were 238 cases of epilepsy surgery,
including 212 anterior temporal lobectomies. Among these, 106 cases had been follow up more than
36 months, and evaluated for surgical results. To evaluate the patient‟s selection and the presurgical
evaluation, we divide the ES cases into the first 5 years (56 cases) and the recent 5 years (182 cases).
But for the purpose of evaluating surgical results, only those with at least 36 months postoperative
follow-up were included (106 cases) and grouped into those operated before or after the age of 25 Yold
(group A and group B), and into those operated before or after the length of epilepsy of 10 years
(group I and group II).
Results: For the first five years-period, decision to operate were based on MRI and routine interictal
EEG in 54 out of 56 TLE cases. One patient had long-term ictal EEG and another had subdural grid
EEG implanted, since MRI in both patients showed visually normal MRI. For the last five years,
decision to operate were based on MRI and routine EEG in 91 out of 156 TLE cases. Long term ictal
EEG were performed in 46 patients, subdural grid EEG in 10 patients, PET study in 7 patients, and
EcoG in 2 patients. The overall seizure free (SF) rate were 70.75%, but if grouped according to
patient‟s age at surgery ( less than or over 25 Y-old ), the SF rates were 75.4% vs 66.04%
respectively. So did if grouped according to length of disease ( less than or more than 10 years ), the
SF rates were 78.72% vs 64.40% respectively.
Conclusions: MRI plays very important role to decide the side of the epileptic temporal side, but this
role is decreasing as it was 96.4% during the beginning five years to become 58.34% for the last five
years. This means that we are working on more difficult epilepsy cases recently. SF rate was
significantly higher for those who was operated at younger age and for those with shorter duration of
epilepsy. This means that surgery should be offered earlier for those intractable TLE patients with
obvious focus on MRI.

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